It is an Institutional requirement that every investigator obtains and documents updated approval of their animal research plan by the Institutional Animal Care and Use Committee (IACUC) as well as the Institutional Biosafety Committee (IBC) for DNA, ES cell and RNA injection projects prior to using the Transgenic Mouse, ICSI and IVF Core.
All information provided by the investigator concerning the research project are treated with the utmost confidentiality. No subject related material will be released to or shared with anyone without a written consent of the principal investigator.
We request that any scientific publications involving transgenic animals acknowledge the services of the Transgenic Mouse, ICSI and IVF Core: “This study was supported in part by Transgenic Mouse, ICSI and IVF Core of the University of Hawaii, which is supported by NIH grant P30GM131944.
NIH has issued a statement supporting and encouraging the timely sharing and distribution of mouse resources generated using NIH funds so that other researchers can benefit from these resources http://modelorganisms.nih.gov/mouse/sharing/1.html.
The term “mouse resources” includes genetically modified mice, inbred mouse strains, mutagenesis protocols, as well as DNA vectors and murine embryonic stem cells used in the production of genetically modified mice. Genetically modified mice are mice in which mutations have been induced by chemicals, irradiation, and transgenesis (e.g., knockouts and injection of DNA into blastocysts), in addition to mice that have had spontaneously occurring mutations.
In addition, all of the transgenic mice generated may be deposited in the Mutant Mouse Regional Resource Centers (MMRRC) http://www.mmrrc.org system. MMRRC cryopreserves embryos and distributes the frozen embryos to biomedical researchers. The MMRRC is a collaborative effort, funded by grants from the National Center for Research Resources (NCRR), NIH.
We would like to remind our users that it’s their responsibility to comply with that statement.
It is the policy of the Core that no injection date will be assigned until the DNA to be injected is submitted, the service request has been completed and the required documents have been provided. The assigned injection date for the will be coordinated with the investigator
For investigators preparing to submit grant proposals to funding agencies, the Transgenic Mouse, ICSI and IVF Core can provide a letter stating our readiness to the requested services.
Core services are on a ‘first come, first served’ basis, with IBR and UH member have priority over non-affiliated requests. Similarly, core services and questions about services are available from moisyadi@hawaii.edu. All requests are approved by an authorized representative of the Core. Users are notified if the requested facility is unavailable and of limitations for use, etc. Requests for urgent attention are considered by Core personnel on an ad hoc basis.